In a recent meta-analysis published in the British Medical Journal, investigators from the University of Montreal reviewed 8 studies, comprising nearly 450,000 patients, connecting the use of common non-steroidal anti-inflammatory agents (NSAIDs) like ibuprofen (Motrin) or naproxen (Aleve) with heart attacks. Overall, they found that use of NSAIDs at any dose for at least a week increased the risk of heart attack 20-50% compared to those who had not used these medications. The risk appeared greatest during the first month of use, particularly if taking high doses of drug. Drilling down to the individual medications, they reported a possible 75% increased risk among users of ibuprofen and naproxen. Because of the size of their study, the investigators state that they can conclude with 90% certainty that NSAID use increases the risk of heart attacks.